alpha-lipoic acid prevents the induction of iNOS gene expression through destabilization of its mRNA in proinflammatory cytokine-stimulated hepatocytes.

Abstract

Results indicate that α-LA inhibits the induction of iNOS gene expression at a posttranscriptional step via iNOS mRNA stabilization, rather than promoter activation.

It may provide useful therapeutic effects through the suppression of iNOS induction involved in liver injury.

Full Text

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Subjects

• Animals
• Antioxidants
• Cells, Cultured
• Gene Expression
• Hepatocytes
• Interleukin-1beta
• L-Lactate Dehydrogenase
• NF-kappa B
• Nitric Oxide Synthase Type II
• Promoter Regions, Genetic
• RNA Stability
• RNA, Messenger
• Rats
• Rats, Wistar
• Receptors, Interleukin-1
• Thioctic Acid
• Transcriptional Activation

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Authors

• Masanori Yamada
• Masaki Kaibori
• Hironori Tanaka
• Kozo Habara
• Takeshi Hijikawa
• Yoshito Tanaka
• Masaharu Oishi
• Tadayoshi Okumura
• Mikio Nishizawa
• A-Hon Kwon

Publication date

2012-03-19

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Digestive diseases and sciences

Department of Surgery, Kansai Medical University, 10-15 Fumizonocho, Moriguchi, Osaka 570-8506, Japan.

Release reference

Dig Dis Sci. 2012 Apr;57(4):943-51

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