PET and MRI of metastatic peritoneal and pulmonary colorectal cancer in mice with human epidermal growth factor receptor 1-targeted 89Zr-labeled panitumumab.

Abstract

The potential utility of (89)Zr-panitumumab in assessing HER1 status in distant metastases and understanding the variations in antibody uptake at different lesion sites is demonstrated in this study. (89)Zr-panitumumab can play a vital role in patient stratification and immunotherapy and therefore warrants further investigation for clinical translation.

Full Text

• DOI - Journal of nuclear medicine : official publication, Society of Nuclear Medicine (DOI)
• ProQuest Information and Learning - full-text online
• HighWire Press - full-text online

Subjects

• Animals
• Antibodies, Monoclonal
• Cell Line, Tumor
• Cell Transformation, Neoplastic
• Colorectal Neoplasms
• Diagnostic Imaging
• Female
• Humans
• Lung Neoplasms
• Magnetic Resonance Imaging
• Mice
• Peritoneal Neoplasms
• Positron-Emission Tomography
• Protein Transport
• Radiochemistry
• Radioisotopes
• Receptor, Epidermal Growth Factor
• Risk Assessment
• Zirconium

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Authors

• Tapan K Nayak
• Kayhan Garmestani
• Diane E Milenic
• Martin W Brechbiel

Publication date

2012-01-03

Journal

Journal topics

• Nuclear Medicine

Language

Eng.

Copyright

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. tapann [at] gmail.com

Release reference

J Nucl Med. 2012 Jan;53(1):113-20

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