The attainment of a certain threshold [Ca(2+)](SR) is not sufficient for the generation of DCWs. Postrelease Ca(2+) signaling refractoriness critically influences the occurrence of DCWs. Shortened Ca(2+) signaling refractoriness due to RyR2 phosphorylation and oxidation is responsible for the increased rate of DCWs observed in VF myocytes and could provide a substrate for synchronization of arrhythmogenic events at the tissue level in hearts prone to VF.
Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W 12th Ave., Columbus, OH 43210, USA.. Andriy.Belevych [at] osumc.edu
Circ Res. 2012 Feb;110(4):569-77
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