Phase I study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma.

Abstract

Combination therapy with sorafenib and temsirolimus resulted in significant toxicity at higher dose levels, failed to achieve any clinical responses in genetically unselected patient population, and did not inhibit P-ERK.

Full Text

• DOI - Clinical cancer research : an official journal of the American Association for Cancer Research (DOI)
• HighWire Press - full-text online

Subjects

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols
• Benzenesulfonates
• Female
• Humans
• Male
• Melanoma
• Middle Aged
• Mutation
• Neoplasm Metastasis
• Neoplasm Staging
• Proto-Oncogene Proteins B-raf
• Pyridines
• Sirolimus
• Survival Analysis
• Treatment Outcome
• Young Adult

Similar articles

• Temsirolimus combined with sorafenib in hepatocellular carcinoma: a phase I dose-finding trial with pharmacokinetic and biomarker correlates. (2013-03-21)
• Safety and treatment patterns of angiogenesis inhibitors in patients with advanced renal cell carcinoma in Spain. (2013-03-20)
• Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02. (2012-10-24)
• Sorafenib in renal cell carcinoma. (2007-01-26)
• Optimal management of metastatic renal cell carcinoma: current status. (2013-04-11)
• Combination targeted therapy in advanced renal cell carcinoma. (2009-05-04)
• Targeted therapy of renal cell cancer. (2008-06-02)
• Treatment Patterns: Targeted Therapies Indicated for First-Line Management of Metastatic Renal Cell Carcinoma in a Real-World Setting. (2012-12-22)
• Opportunities and obstacles to combination targeted therapy in renal cell cancer. (2007-01-26)

Authors

• Michael A Davies
• Patricia S Fox
• Nicholas E Papadopoulos
• Agop Y Bedikian
• Wen-Jen Hwu
• Alexander J Lazar
• Victor G Prieto
• Kirk S Culotta
• Timothy L Madden
• Quanyun Xu
• Sha Huang
• Wanleng Deng
• Chaan S Ng
• Sanjay Gupta
• Wenbin Liu
• Janet E Dancey
• John J Wright
• Roland

Publication date

2012-02-16

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Clinical cancer research : an official journal of the American Association for Cancer Research

Departments of Melanoma Medical Oncology, Systems Biology, Biostatistics, Pathology, Experimental Therapeutics, and Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Release reference

Clin Cancer Res. 2012 Feb;18(4):1120-8

Related books

• Books of Antineoplastic Combined Chemotherapy Protocols
• Books of Benzenesulfonates
• Books of Melanoma
• Books of Mutation
• Books of Neoplasm Metastasis
• Books of Neoplasm Staging
• Books of Neoplasms
• Books of Proto-Oncogene Proteins B-raf
• Books of Pyridines
• Books of Sirolimus
• Books of Survival Analysis
• Books of Treatment Outcome