Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists. Colon-targeted, intraluminal delivery of 5-HT(4)R agonists might be used to promote motility and alleviate visceral pain, while restricting systemic bioavailability and resulting adverse side effects.
Department of Anatomy & Neurobiology, University of Vermont, Burlington, Vermont 05405, USA.
Gastroenterology. 2012 Apr;142(4):844-854.e4
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