Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

Abstract

Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists. Colon-targeted, intraluminal delivery of 5-HT(4)R agonists might be used to promote motility and alleviate visceral pain, while restricting systemic bioavailability and resulting adverse side effects.

Full Text

• DOI - Gastroenterology (DOI)
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Subjects

• Administration, Oral
• Analgesics
• Animals
• Chlorides
• Chromosomes, Artificial, Bacterial
• Colon
• Disease Models, Animal
• Enterochromaffin Cells
• Gastrointestinal Agents
• Gastrointestinal Motility
• Goblet Cells
• Green Fluorescent Proteins
• Guinea Pigs
• Humans
• Hyperalgesia
• Immunohistochemistry
• Intestinal Mucosa
• Male
• Membrane Potentials
• Mice
• Mice, Inbred BALB C
• Mice, Transgenic
• Mucus
• Pain
• Pain Threshold
• Pressure
• Rats
• Rats, Sprague-Dawley
• Receptors, Serotonin, 5-HT4
• Reverse Transcriptase Polymerase Chain Reaction
• Serotonin
• Serotonin 5-HT4 Receptor Agonists

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Authors

• Jill M Hoffman
• Karl Tyler
• Sarah J MacEachern
• Onesmo B Balemba
• Anthony C Johnson
• Elice M Brooks
• Hong Zhao
• Greg M Swain
• Peter L Moses
• James J Galligan
• Keith A Sharkey
• Beverley Greenwood-Van Meerveld
• Gary M Mawe

Publication date

2012-04-06

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Gastroenterology

Department of Anatomy & Neurobiology, University of Vermont, Burlington, Vermont 05405, USA.

Release reference

Gastroenterology. 2012 Apr;142(4):844-854.e4

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