Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.

Abstract

These data indicate that telomestatin potently eradicates GSCs through telomere disruption and c-Myb inhibition, and this study suggests a novel GSC-directed therapeutic strategy for GBMs.

Full Text

• DOI - Clinical cancer research : an official journal of the American Association for Cancer Research (DOI)
• HighWire Press - full-text online

Subjects

• Animals
• Antineoplastic Agents
• Cell Line, Tumor
• Cell Movement
• Cell Proliferation
• Cell Survival
• DNA Damage
• G-Quadruplexes
• Gene Expression
• Genes, myb
• Glioma
• Humans
• Mice
• Neoplastic Stem Cells
• Neural Stem Cells
• Oxazoles
• Xenograft Model Antitumor Assays

Similar articles

• Localization of c-Myb and induction of apoptosis by antisense oligonucleotide c-Myb after angioplasty of porcine coronary arteries. (2001-11-09)
• FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. (2008-08-07)
• Disruption of B-myb in DT40 cells reveals novel function for B-Myb in the response to DNA-damage. (2005-11-03)
• Induction of apoptosis in K562 cells by dominant negative c-myb. (2002-10-17)
• Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation. (2012-08-14)
• Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. (2008-02-29)
• Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. (2003-08-27)
• c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression. (2010-11-26)
• Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice. (2012-08-23)

Authors

• Takeshi Miyazaki
• Yang Pan
• Kaushal Joshi
• Deepti Purohit
• Bin Hu
• Habibe Demir
• Sarmistha Mazumder
• Sachiko Okabe
• Takao Yamori
• Mariano Viapiano
• Kazuo Shin-ya
• Hiroyuki Seimiya
• Ichiro Nakano

Publication date

2012-03-05

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Clinical cancer research : an official journal of the American Association for Cancer Research

Department of Neurological Surgery, Dardinger, Center for Neuro-oncology, James Cancer Hospital and The Ohio State University, Columbus, Ohio 43210, USA.

Release reference

Clin Cancer Res. 2012 Mar;18(5):1268-80

Related books

• Books of Animals
• Books of Antineoplastic Agents
• Books of Cell Line, Tumor
• Books of Cell Movement
• Books of Cell Proliferation
• Books of Cell Survival
• Books of DNA Damage
• Books of G-Quadruplexes
• Books of Gene Expression
• Books of Genes, myb
• Books of Glioma
• Books of Mice
• Books of Neoplasms
• Books of Neoplastic Stem Cells
• Books of Neural Stem Cells
• Books of Oxazoles
• Books of Xenograft Model Antitumor Assays