11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder.

Abstract

Middle-aged HIV-positive participants, even with HAND, do not exhibit increased (11)C-PiB levels, whereas symptomatic AD individuals have increased fibrillar Aβ42 deposition in cortical and subcortical regions.

Observed dissimilarities between HAND and AD may reflect differences in Aβ42 metabolism. (11)C-PiB may provide a diagnostic biomarker for distinguishing symptomatic AD from HAND in middle-aged HIV-positive participants.

Future cross-sectional and longitudinal studies are required to assess the utility of (11)C-PiB in older individuals with HAND.

Full Text

• DOI - (DOI)
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• Adult
• Aged
• Aged, 80 and over
• Alzheimer Disease
• Amyloid beta-Peptides
• Apolipoproteins E
• Benzothiazoles
• Case-Control Studies
• Cerebral Cortex
• Cognition Disorders
• Female
• HIV Infections
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Peptide Fragments
• Positron-Emission Tomography

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Authors

• Beau M Ances
• Tammie L Benzinger
• Jon J Christensen
• Jewell Thomas
• Rohit Venkat
• Mengesha Teshome
• Patricia Aldea
• Anne M Fagan
• David M Holtzman
• John C Morris
• David B Clifford

Publication date

2012-01-10

Journal

Journal topics

• Neurology

Language

Eng.

Copyright

Department of Neurology, Washington University in St. Louis, Campus Box 8111, 660 S Euclid Ave, St Louis, MO 63110, USA. bances [at] wustl.edu

Release reference

Arch Neurol. 2012 Jan;69(1):72-7

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