Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G.

Abstract

These data highlight the usefulness of mapping disease susceptibility loci using a transancestral approach, particularly in a region as complex as the MHC, and offer a springboard for further fine-mapping, resequencing and transcriptomic analysis.

Full Text

• DOI - Annals of the rheumatic diseases (DOI)
• UK PubMed Central - full-text online
• PubMed Central - full-text online
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• Lippincott Williams & Wilkins - full-text online
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Subjects

• Case-Control Studies
• Cell Cycle Proteins
• Chromosome Mapping
• Cohort Studies
• Ethnic Groups
• Genetic Markers
• Genetic Predisposition to Disease
• HLA-DP beta-Chains
• HLA-G Antigens
• Humans
• Lupus Erythematosus, Systemic
• Major Histocompatibility Complex
• Philippines
• Polymorphism, Single Nucleotide
• Spain

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Authors

• Michelle M A Fernando
• Jan Freudenberg
• Annette Lee
• David Lester Morris
• Lora Boteva
• Benjamin Rhodes
• María Francisca Gonzalez-Escribano
• Miguel Angel Lopez-Nevot
• Sandra V Navarra
• Peter K Gregersen
• Javier Martin
• Timothy J Vyse

Publication date

2012-04-11

Journal

Journal topics

• Rheumatic Diseases

Language

Eng.

Copyright

Annals of the rheumatic diseases

Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK. michelle.fernando [at] kcl.ac.uk

Release reference

Ann Rheum Dis. 2012 May;71(5):777-84

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