Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells.

Abstract

miR-28-5p and miR-28-3p are transcribed from the same RNA hairpin and are down-regulated in CRC cells.

Overexpression of each has different effects on CRC cell proliferation and migration.

Such information has a direct application for the design of miRNA gene therapy trials.

Full Text

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Subjects

• Animals
• Apoptosis
• Case-Control Studies
• Cell Movement
• Cell Proliferation
• Colorectal Neoplasms
• Cyclin D1
• G1 Phase Cell Cycle Checkpoints
• Gene Expression Regulation, Neoplastic
• Gene Therapy
• HCT116 Cells
• Homeodomain Proteins
• Humans
• Mice
• Mice, Inbred NOD
• Mice, Knockout
• Mice, SCID
• MicroRNAs
• NM23 Nucleoside Diphosphate Kinases
• Neoplasm Invasiveness
• RNA Interference
• Real-Time Polymerase Chain Reaction
• Receptors, Interleukin-2
• Reverse Transcriptase Polymerase Chain Reaction
• Time Factors
• Transfection
• Tumor Burden
• Xenograft Model Antitumor Assays

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Authors

• Maria I Almeida
• Milena S Nicoloso
• Lizhi Zeng
• Cristina Ivan
• Riccardo Spizzo
• Roberta Gafà
• Lianchun Xiao
• Xinna Zhang
• Ivan Vannini
• Francesca Fanini
• Muller Fabbri
• Giovanni Lanza
• Rui M Reis
• Patrick A Zweidler-McKay
• George A Calin

Publication date

2012-04-06

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Gastroenterology

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Release reference

Gastroenterology. 2012 Apr;142(4):886-896.e9

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