Estrogen can repress transcription of HBV genes by up-regulating ER-α, which interacts with and alters binding of HNF-4α to the HBV enhancer I. These findings might account for the lower viral load and reduced incidence of liver cancer in HBV-infected women than men.
Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Gastroenterology. 2012 Apr;142(4):989-998.e4
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