Phase I study of lapatinib plus vinorelbine in patients with locally advanced or metastatic breast cancer overexpressing HER2.

Abstract

The MTD LPT 1000 mg/VNR 22.5 mg m(-2) (DL3) is recommended for additional development.

Pharmacokinetic interactions might increase the exposure to VNR and consequently alter the hematological tolerance.

Full Text

• DOI - British journal of cancer (DOI)
• Swets Information Services - full-text online
• Nature Publishing Group - full-text online
• EBSCO - full-text online

Subjects

• Adult
• Aged
• Antibodies, Monoclonal, Humanized
• Antineoplastic Combined Chemotherapy Protocols
• Breast Neoplasms
• Drug Administration Schedule
• Drug Resistance, Neoplasm
• Feasibility Studies
• Female
• Humans
• Maximum Tolerated Dose
• Middle Aged
• Quinazolines
• Receptor, erbB-2
• Vinblastine

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Authors

• E Brain
• N Isambert
• F Dalenc
• V Diéras
• J Bonneterre
• K Rezai
• M Jimenez
• F Mefti-Lacheraf
• E Cottura
• P Tresca
• L Vanlemmens
• C Mahier-Aït Oukhatar
• F Lokiec
• P Fumoleau

Publication date

2012-02-15

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

British journal of cancer

Department of Medical Oncology, Institut Curie - Hôpital René Huguenin 35 rue Daily, 92210 Saint-Cloud, France. etienne.brain [at] curie.net

Release reference

Br J Cancer. 2012 Feb;106(4):673-7

Related books

• Books of Antibodies, Monoclonal, Humanized
• Books of Antineoplastic Combined Chemotherapy Protocols
• Books of Breast Neoplasms
• Books of Drug Administration Schedule
• Books of Drug Resistance, Neoplasm
• Books of Feasibility Studies
• Books of Maximum Tolerated Dose
• Books of Neoplasms
• Books of Quinazolines
• Books of Receptor, erbB-2
• Books of Vinblastine