Aspirin prevents resistin-induced endothelial dysfunction by modulating AMPK, ROS, and Akt/eNOS signaling.

Abstract

Our findings suggest a direct connection between adipocytokines and endothelial dysfunction and provide further insight into the protective effects of aspirin in obese individuals with endothelial dysfunction.

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Subjects

• AMP-Activated Protein Kinases
• Analysis of Variance
• Aspirin
• Cells, Cultured
• Culture Media, Conditioned
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Enzyme-Linked Immunosorbent Assay
• Human Umbilical Vein Endothelial Cells
• Humans
• Immunoblotting
• NADP
• Nitric Oxide Synthase
• Proto-Oncogene Proteins c-akt
• RNA, Small Interfering
• Reactive Oxygen Species
• Real-Time Polymerase Chain Reaction
• Reference Values
• Resistin
• Sensitivity and Specificity
• Signal Transduction

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Authors

• Hsiu-Chung Ou
• Wen-Jane Lee
• Ching-Mei Wu
• Judy Fuh-Meei Chen
• Wayne Huey-Herng Sheu

Publication date

2012-04-02

Journal

Journal topics

• Vascular Surgical Procedures

Language

Eng.

Copyright

Department of Physical Therapy and Graduate, Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan, Republic of China.

Release reference

J Vasc Surg. 2012 Apr;55(4):1104-15

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