Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice.

Abstract

Notch1 signaling is required for vascular homeostasis of hepatic sinusoids; it maintains quiescence and differentiation of LSECs in adult mice.

Disruption of Notch1 signaling in LSECs leads to spontaneous formation of angiosarcoma, indicating its role as a tumor suppressor in the liver endothelium.

Full Text

• DOI - Gastroenterology (DOI)
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Subjects

• Animals
• Cell Dedifferentiation
• Cell Proliferation
• Cell Transformation, Neoplastic
• Cells, Cultured
• Endothelial Cells
• Ephrin-B2
• Focal Nodular Hyperplasia
• Genotype
• Hemangiosarcoma
• Hepatocytes
• Humans
• Hypertension, Portal
• Liver
• Liver Neoplasms
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Microscopy, Electron, Scanning
• Neovascularization, Pathologic
• Phenotype
• Portal Pressure
• Receptor, EphB4
• Receptor, Notch1
• Signal Transduction
• Time Factors

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Authors

• Michael T Dill
• Sonja Rothweiler
• Valentin Djonov
• Ruslan Hlushchuk
• Luigi Tornillo
• Luigi Terracciano
• Silvia Meili-Butz
• Freddy Radtke
• Markus H Heim
• David Semela

Publication date

2012-04-06

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Gastroenterology

Department of Biomedicine, University Basel, Basel, Switzerland.

Release reference

Gastroenterology. 2012 Apr;142(4):967-977.e2

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