The analgesic activity of intrathecal tianeptine, an atypical antidepressant, in a rat model of inflammatory pain.

Abstract

Intrathecally administered tianeptine effectively relieved inflammatory pain in rats.

The serotonergic system is related to the activity of tianeptine for facilitated pain at the spinal level.

Adrenergic transmission is also involved in tianeptine-induced analgesia for both facilitated and acute pain.

The combination of tianeptine and cyclooxygenase-2 inhibitor may provide additional benefits for the management of inflammatory pain.

Full Text

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Subjects

• Analgesics
• Animals
• Antidepressive Agents, Second-Generation
• Disease Models, Animal
• Inflammation Mediators
• Injections, Spinal
• Male
• Pain
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Thiazepines

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Authors

• Woong Mo Kim
• Seong Heon Lee
• Hye Jin Jeong
• Hyung Gon Lee
• Jeong Il Choi
• Myung Ha Yoon

Publication date

2012-02-23

Journal

Journal topics

• Anesthesiology

Language

Eng.

Copyright

Anesthesia and analgesia

Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 8 Hakdong, Donggu, Gwangju 501-757, Korea.

Release reference

Anesth Analg. 2012 Mar;114(3):683-9

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