Exposure to pyocyanin alters urothelial cell viability, reactive oxygen species production and caspase-3 activity.
Treatment also results in cellular senescence, which may affect the ability of urothelium to repair during infection.
The virulence factor depressed stimulated adenosine triphosphate release, which to our knowledge is a novel finding with implications for awareness of bladder filling in patients with P. aeruginosa urinary tract infection.
2012-02-13
Eng.
The Journal of urology
Department of Biomedical Science, Bond University, Queensland, Australia.
J Urol. 2012 Mar;187(3):1087-93
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