Impact of IL-1 signalling on experimental uveitis and arthritis.

Abstract

This study demonstrates that IL-1Ra plays an important role in suppressing local responses in eyes injected with LPS and that there is discordance between murine eyes and joints in the extent to which IL-1Ra protects against spontaneous inflammation.

Full Text

• DOI - Annals of the rheumatic diseases (DOI)
• UK PubMed Central - full-text online
• PubMed Central - full-text online
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
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Subjects

• Animals
• Arthritis
• Disease Models, Animal
• Eye
• Female
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1
• Joints
• Lipopolysaccharides
• Mice
• Mice, Inbred BALB C
• Mice, Knockout
• Microscopy, Video
• Organ Specificity
• Signal Transduction
• Uveitis

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Authors

• Stephen R Planck
• April Woods
• Jenna S Clowers
• Martin J Nicklin
• James T Rosenbaum
• Holly L Rosenzweig

Publication date

2012-04-11

Journal

Journal topics

• Rheumatic Diseases

Language

Eng.

Copyright

Annals of the rheumatic diseases

Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Release reference

Ann Rheum Dis. 2012 May;71(5):753-60

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