Calpastatin controls polymicrobial sepsis by limiting procoagulant microparticle release.

Abstract

These results demonstrate an important role of the calpain/calpastatin system in coagulation/inflammation pathways during sepsis, because calpain inhibition is associated with less severe disseminated intravascular coagulation and better overall outcomes in sepsis.

Full Text

• DOI - American journal of respiratory and critical care medicine (DOI)
• ProQuest Information and Learning - full-text online
• HighWire Press - full-text online

Subjects

• Animals
• Apoptosis
• Calcium-Binding Proteins
• Calpain
• Cell-Derived Microparticles
• Cytokines
• Disease Models, Animal
• Disseminated Intravascular Coagulation
• Lymphocytes
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Multiple Organ Failure
• NF-kappa B
• Sepsis
• Thromboplastin

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Authors

• Lara Zafrani
• Grigoris Gerotziafas
• Colleen Byrnes
• Xuzhen Hu
• Joelle Perez
• Charlène Lévi
• Sandrine Placier
• Emmanuel Letavernier
• Asada Leelahavanichkul
• Jean-philippe Haymann
• Ismail Elalamy
• Jeffrey L Miller
• Robert A Star
• Peter S T Yuen
• Laurent Baud

Publication date

2012-04-02

Journal

Journal topics

• Critical Care
• Respiratory Tract Diseases

Language

Eng.

Copyright

American journal of respiratory and critical care medicine

Université Pierre et Marie Curie, Paris VI, UMR S 702, Paris, France. larazafrani [at] hotmail.com

Release reference

Am J Respir Crit Care Med. 2012 Apr;185(7):744-55

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