The study concluded, we believe for the first time, an increased activation of the HIF pathway, with upregulation of the expression of HIF-1α and HIF-2α transcription factors, and HIF target genes, in VVs compared with NVVs. Exposure of VVs and NVVs to hypoxic conditions was associated with increased expression of HIF-1α and HIF-2α protein and HIF target genes.
The data suggest that the HIF pathway may be associated with several pathophysiologic changes in the VV wall, and that hypoxia may be a feature contributing to VV pathogenesis.
2012-04-30
Eng.
Academic Section of Vascular Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom.
J Vasc Surg. 2012 May;55(5):1427-39
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