Transient expression of progesterone receptor and cathepsin-l in human granulosa cells during the periovulatory period.

Abstract

The transient expression of PR in human GCs of the preovulatory follicle suggests that PR and its ligand play a role in the activation of cathepsin-L, which is presumably involved in the degradation of the follicular extracellular matrix during human ovulation.

Full Text

• DOI - Fertility and sterility (DOI)
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Subjects

• Adult
• Blotting, Western
• Cathepsin L
• Cells, Cultured
• Chorionic Gonadotropin
• Cyclic AMP-Dependent Protein Kinases
• Enzyme Activation
• Female
• Fertility Agents, Female
• Follicular Fluid
• Granulosa Cells
• Hormone Antagonists
• Humans
• Ovulation
• Ovulation Induction
• Protein Kinase Inhibitors
• RNA, Messenger
• Real-Time Polymerase Chain Reaction
• Receptors, Progesterone
• Time Factors

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Authors

• Víctor García
• Paulina Kohen
• Carola Maldonado
• Walter Sierralta
• Alex Muñoz
• Claudio Villarroel
• Jerome F Strauss
• Luigi Devoto

Publication date

2012-03-02

Journal

Journal topics

• Fertility
• Infertility

Language

Eng.

Copyright

Fertility and sterility

Institute for Maternal and Child Research, IDIMI, and Department of Obstetrics and Gynecology, Faculty of Medicine, San Borja-Arriaran Clinical Hospital, University of Chile, Santiago, Chile.

Release reference

Fertil Steril. 2012 Mar;97(3):707-13.e1

Related books

• Books of Blotting, Western
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• Books of Cells, Cultured
• Books of Chorionic Gonadotropin
• Books of Cyclic AMP-Dependent Protein Kinases
• Books of Enzyme Activation
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• Books of Protein Kinase Inhibitors
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