Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level.

Abstract

Melanoma cells show clonal heterogeneity. Therefore, CTC genotyping may be crucial for successful molecular-targeted therapy.

Full Text

• DOI - British journal of cancer (DOI)
• Swets Information Services - full-text online
• Nature Publishing Group - full-text online
• EBSCO - full-text online

Subjects

• Aged
• Aged, 80 and over
• Antibodies, Monoclonal
• Antigens, Neoplasm
• Base Sequence
• Cell Line, Tumor
• Cell Separation
• DNA Mutational Analysis
• Female
• Genes, ras
• Genotype
• Humans
• Immunomagnetic Separation
• MART-1 Antigen
• Male
• Melanoma
• Middle Aged
• Molecular Targeted Therapy
• Mutation
• Neoplasm Proteins
• Neoplastic Cells, Circulating
• Proto-Oncogene Proteins B-raf
• Proto-Oncogene Proteins c-kit
• Sequence Analysis, DNA
• Single-Cell Analysis
• Skin Neoplasms

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Authors

• K Sakaizawa
• Y Goto
• Y Kiniwa
• A Uchiyama
• K Harada
• S Shimada
• T Saida
• S Ferrone
• M Takata
• H Uhara
• R Okuyama

Publication date

2012-02-29

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

British journal of cancer

Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.

Release reference

Br J Cancer. 2012 Feb;106(5):939-46

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