ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion.

Abstract

The potency, pharmacokinetic profile, and SC bioavailability of ARC15105 support its clinical investigation for chronic inhibition of von Willeband factor -mediated platelet activation.

Full Text

• DOI - Arteriosclerosis, thrombosis, and vascular biology (DOI)
• Swets Information Services - full-text online
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online

Subjects

• Aged
• Animals
• Aptamers, Nucleotide
• Aptamers, Peptide
• Austria
• Biological Availability
• Blood Platelets
• Boston
• Case-Control Studies
• Collagen
• Cross-Sectional Studies
• Dose-Response Relationship, Drug
• Drug Stability
• Female
• Half-Life
• Humans
• Injections, Intravenous
• Injections, Subcutaneous
• Macaca fascicularis
• Male
• Middle Aged
• Myocardial Infarction
• Platelet Activation
• Platelet Adhesiveness
• Platelet Aggregation Inhibitors
• Platelet Function Tests
• Protein Binding
• Quebec
• Rats
• Swine
• von Willebrand Factor

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Authors

• Jolanta M Siller-Matula
• Yahye Merhi
• Jean-François Tanguay
• Daniel Duerschmied
• Denisa D Wagner
• Kathleen E McGinness
• P Shannon Pendergrast
• Jou-Ku Chung
• Xianbin Tian
• Robert G Schaub
• Bernd Jilma

Publication date

2012-03-16

Journal

Journal topics

• Arteriosclerosis
• Thrombosis
• Vascular Diseases

Language

Eng.

Copyright

Arteriosclerosis, thrombosis, and vascular biology

Department of Cardiology, Medical University of Vienna, Austria.

Release reference

Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):902-9

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