Dexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.

Abstract

Dexamethasone administration before arterial switch operation leads to a shift in the myocardial and systemic cytokine expression profile in neonates with transposition of the great arteries, with downregulation of proinflammatory and upregulation of antiinflammatory cytokines.

Lower myocardial cell damage and lower catecholamine requirement suggest myocardial protection in treated patients.

Full Text

• DOI - The Annals of thoracic surgery (DOI)
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Subjects

• Anti-Inflammatory Agents
• Cardiac Surgical Procedures
• Cardiomyopathies
• Cardiopulmonary Bypass
• Cytokines
• Dexamethasone
• Double-Blind Method
• Humans
• Infant, Newborn
• Inflammation
• Postoperative Complications
• Preoperative Care
• Prospective Studies
• Transposition of Great Vessels

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Authors

• Ruth Heying
• Edith Wehage
• Katharina Schumacher
• Peter Tassani
• Felix Haas
• Rudiger Lange
• John Hess
• Marie-Christine Seghaye

Publication date

2012-02-27

Journal

Journal topics

• Thoracic Diseases

Language

Eng.

Copyright

The Annals of thoracic surgery

Department of Pediatric Cardiology, University Hospital Aachen, Aachen, Germany. ruth.heying [at] uzleuven.be

Release reference

Ann Thorac Surg. 2012 Mar;93(3):869-76

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