The immunoproteasome is a specific proteasome isoform induced by interferons.
Its proteolytic function has been almost exclusively connected with the adaptive immune response and improved MHC class I antigen presentation. However, IFN-signaling also exposes cells to oxidative stress with concomitant production of nascent-oxidant damaged poly-ubiquitylated proteins.
Here we discuss how immunoproteasomes protect cells against accumulation of toxic protein-aggregates and how i-proteasomes dysfunction associates with different diseases.
We propose that the immunoproteasome has a central function at the interface between the innate and adaptive immune response and that its predominant protective innate function determines its favorable role in the adaptive immune response.
2012-02-20
Eng.
Charité - Universitätsmedizin Berlin, Institut für Biochemie CVK, Oudenarder Str. 16, 13347 Berlin, Germany.
Curr Opin Immunol. 2012 Feb;24(1):77-83
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