Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice.

Abstract

Endocannabinoids contribute to diet-induced insulin resistance in mice via hepatic CB(1)-mediated inhibition of insulin signaling and clearance.

Full Text

• DOI - Gastroenterology (DOI)
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Subjects

• Animals
• Arachidonic Acids
• Diet, High-Fat
• Endoplasmic Reticulum Stress
• Fatty Liver
• Glucose Intolerance
• Humans
• Insulin
• Insulin Resistance
• Liver
• Male
• Metabolic Clearance Rate
• Mice
• Mice, Inbred C57BL
• Phosphorylation
• Polyunsaturated Alkamides
• Proto-Oncogene Proteins c-akt
• Receptor, Cannabinoid, CB1
• Signal Transduction

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Authors

• Jie Liu
• Liang Zhou
• Keming Xiong
• Grzegorz Godlewski
• Bani Mukhopadhyay
• Joseph Tam
• Shi Yin
• Peter Gao
• Xin Shan
• James Pickel
• Ramon Bataller
• James O'Hare
• Thomas Scherer
• Christoph Buettner
• George Kunos

Publication date

2012-04-24

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Gastroenterology

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9413, USA. jiel [at] mail.nih.gov

Release reference

Gastroenterology. 2012 May;142(5):1218-1228.e1

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