Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.

Abstract

Although euploidy rate decreased on average with advancing maternal age, the high intra-age and intercenter variation in oocyte chromosome abnormalities emphasize the difficulty in estimating how many euploid oocytes a specific woman will have.

This may have repercussions for fertility preservation where a defined number of eggs are currently frozen just based on maternal age.

Full Text

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Subjects

• Adult
• Age Factors
• Aneuploidy
• Biopsy
• Chromosome Aberrations
• Chromosomes, Human
• Cryopreservation
• Female
• Fertility Agents, Female
• Genetic Testing
• Germany
• Health Facilities
• Humans
• In Situ Hybridization, Fluorescence
• Infertility
• Italy
• Linear Models
• Meiosis
• Middle Aged
• Oocytes
• Ovulation
• Ovulation Induction
• Polar Bodies
• Preimplantation Diagnosis
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Time Factors

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Authors

• Santiago Munné
• Karsten R Held
• Cristina M Magli
• Baris Ata
• Dagan Wells
• Elpida Fragouli
• Vera Baukloh
• Robert Fischer
• Luca Gianaroli

Publication date

2012-04-02

Journal

Journal topics

• Fertility
• Infertility

Language

Eng.

Copyright

Fertility and sterility

Reprogenetics, Livingston, New Jersey, USA. munne [at] reprogenetics.com

Release reference

Fertil Steril. 2012 Apr;97(4):935-42

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