Success of intra-arterial chemotherapy (chemosurgery) for retinoblastoma: effect of orbitovascular anatomy.

Abstract

The success of intra-arterial chemotherapy is dependent on delivery of drug to the target tumor within the eye via the ophthalmic artery.

Because of the small volume of drug used (0.50-1.25 mL per treatment) and the selectivity of catheterization, variables affecting orbital blood flow greatly influence drug delivery and the success of chemosurgery.

Full Text

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Subjects

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols
• Blood Flow Velocity
• Carboplatin
• Child
• Child, Preschool
• Female
• Fluorescein Angiography
• Humans
• Infant
• Infusions, Intra-Arterial
• Male
• Melphalan
• Ophthalmic Artery
• Orbit
• Regional Blood Flow
• Retinal Neoplasms
• Retinoblastoma
• Topotecan
• Young Adult

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Authors

• Brian P Marr
• Crystal Hung
• Yves P Gobin
• Ira J Dunkel
• Scott E Brodie
• David H Abramson

Publication date

2012-02-14

Journal

Journal topics

• Ophthalmology

Language

Eng.

Copyright

Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Release reference

Arch Ophthalmol. 2012 Feb;130(2):180-5

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