A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling.

Abstract

T cell-specific ΔE2Smurf2 degrades wild-type Smurf2 and controls intestinal tumor growth in mice by up-regulating TGF-β receptor type II, reducing proliferation and production of proinflammatory cytokines.

Full Text

• DOI - Gastroenterology (DOI)
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Subjects

• Animals
• Antigens, CD44
• Cells, Cultured
• Colitis
• Colonic Neoplasms
• Gene Expression Profiling
• Mice
• Mice, Inbred C57BL
• Proto-Oncogene Proteins c-kit
• Receptors, G-Protein-Coupled
• Signal Transduction
• Transforming Growth Factor beta
• Ubiquitin-Protein Ligases

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Authors

• Heike Dornhoff
• Christoph Becker
• Stefan Wirtz
• Dennis Strand
• Stefan Tenzer
• Susanne Rosfa
• Clemens Neufert
• Jonas Mudter
• Jürgen Markl
• Jürgen Siebler
• Markus F Neurath

Publication date

2012-04-24

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Gastroenterology

Department of Medicine, University of Erlangen-Nuremberg, Erlangen and Nuremberg, Germany.

Release reference

Gastroenterology. 2012 May;142(5):1183-1194.e4

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