The impairment of reproduction in db/db mice is not mediated by intraovarian defective leptin signaling.

Abstract

We confirmed that impairment of reproduction in intact db/db mice is not mediated by intraovary intact/defective leptin signaling even in face of a divergent modulation by gonadotropins.

Full Text

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Subjects

• Animals
• Aromatase
• Diabetes Mellitus
• Disease Models, Animal
• Estradiol
• Female
• Follicle Stimulating Hormone
• Genotype
• Janus Kinase 2
• Leptin
• Mice
• Mice, 129 Strain
• Mice, Inbred C57BL
• Mice, Mutant Strains
• Mutation
• Ovary
• Phenotype
• Phosphoproteins
• Protein Inhibitors of Activated STAT
• RNA, Messenger
• Receptors, Leptin
• Reproduction
• Reverse Transcriptase Polymerase Chain Reaction
• STAT3 Transcription Factor
• Signal Transduction
• Steroid 17-alpha-Hydroxylase
• Time Factors
• Transplantation, Homologous

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Authors

• Yuehui Zhang
• Min Hu
• Hongxia Ma
• Junwei Qu
• Yong Wang
• Lihui Hou
• Li Liu
• Xiao-Ke Wu

Publication date

2012-04-30

Journal

Journal topics

• Fertility
• Infertility

Language

Eng.

Copyright

Fertility and sterility

Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.

Release reference

Fertil Steril. 2012 May;97(5):1183-91

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