Evaluation of breast tumor blood flow with dynamic first-pass 18F-FDG PET/CT: comparison with angiogenesis markers and prognostic factors.

Abstract

Tumor blood flow quantified by dynamic first-pass (18)F-FDG PET/CT is significantly associated with tumor angiogenesis as evaluated by immunohistochemistry in the setting of breast cancer, whereas tumor metabolism appears to be more associated with markers of proliferation. Thus, determination of tumor blood flow and metabolism with a single injection of (18)F-FDG could be an exciting alternative to more complex and less available techniques.

Full Text

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Subjects

• Adult
• Aged
• Blood Circulation
• Breast Neoplasms
• Cell Proliferation
• Endothelial Cells
• Female
• Fluorodeoxyglucose F18
• Humans
• Logistic Models
• Middle Aged
• Neovascularization, Pathologic
• Positron-Emission Tomography and Computed Tomography
• Prognosis
• Prospective Studies
• Tumor Markers, Biological

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Authors

• Alexandre Cochet
• Sophie Pigeonnat
• Blandine Khoury
• Jean-Marc Vrigneaud
• Claude Touzery
• Alina Berriolo-Riedinger
• Inna Dygai-Cochet
• Michel Toubeau
• Olivier Humbert
• Bruno Coudert
• Pierre Fumoleau
• Laurent Arnould
• François Brunotte

Publication date

2012-04-04

Journal

Journal topics

• Nuclear Medicine

Language

Eng.

Copyright

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Department of Nuclear Medicine, Centre Georges-François Leclerc, Dijon, France. acochet [at] cgfl.fr

Release reference

J Nucl Med. 2012 Apr;53(4):512-20

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