Similar to the mandible, the maxilla is susceptible to radiogenic bone injury as demonstrated by the significant decrease in bone volume of the radiated dental extraction socket.
Despite radiologic similarities to mandibular ORN in the rat model, the maxilla demonstrated a more benign clinical course with a complete absence of bone exposure.
Differences in the maxillary bone and microenvironment of the maxilla compared with the mandible may explain the subclinical response to radiation and lower incidence of maxillary ORN seen in patients.
This maxillary model can be combined with our high-dose-rate mandibular ORN model to investigate these differences and better understand ORN.
2012-02-21
Eng.
Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Arch Otolaryngol Head Neck Surg. 2012 Feb;138(2):167-71
© Galenicom 1999-2013