Matrix metalloproteinases and tissue inhibitors of metalloproteinases in nasal lavage after an inhalation challenge with flour.

Abstract

This study showed that after an inhalation challenge with an occupational allergen, the nasal mucosa displayed an imbalance in favor of TIMPs enzymes activity as compared to MMPs enzymes activity, represented in an increase in nasal levels of TIMP-2 during the course of the early reaction following the allergen challenge.

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Subjects

• Adult
• Air Pollutants
• Air Pollutants, Occupational
• Flour
• Follow-Up Studies
• Humans
• Male
• Nasal Lavage Fluid
• Nasal Mucosa
• Occupational Diseases
• Rhinitis, Allergic, Perennial
• Rhinometry, Acoustic
• Tissue Inhibitor of Metalloproteinases

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Authors

• Roberto Castano
• David Miedinger
• Karim Maghni
• Heberto Ghezzo
• Carole Trudeau
• Lucero Castellanos
• Mathieu Wattiez
• Olivier Vandenplas
• Jean-Luc Malo

Publication date

2012-03-21

Journal

Journal topics

• Otolaryngology

Language

Eng.

Copyright

Department of Surgery/Otolaryngology, Sacre-Coeur Hospital, Montreal, Quebec, Canada. roberto.castano [at] umontreal.ca

Release reference

Laryngoscope. 2012 Apr;122(4):730-5

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