Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer.

Abstract

IL-8 is an independent prognostic factor irrespective of treatment.

There is an interaction between HGF and treatment arm.

Certain subgroups based on IL-8/HGF levels seemed to do better with TPZ/CIS while others did worse, highlighting the complexity of hypoxia targeting in unselected patients.

Full Text

• DOI - Clinical cancer research : an official journal of the American Association for Cancer Research (DOI)
• HighWire Press - full-text online

Subjects

• Antineoplastic Combined Chemotherapy Protocols
• Carcinoma, Squamous Cell
• Chemoradiotherapy
• Female
• Head and Neck Neoplasms
• Hepatocyte Growth Factor
• Humans
• Interleukin-8
• Male
• Middle Aged
• Positron-Emission Tomography
• Triazines
• Tumor Markers, Biological

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Authors

• Quynh-Thu Le
• Richard Fisher
• Kelly S Oliner
• Richard J Young
• Hongbin Cao
• Christina Kong
• Edward Graves
• Rodney J Hicks
• Grant A McArthur
• Lester Peters
• Brian O'Sullivan
• Amato Giaccia
• Danny Rischin

Publication date

2012-03-16

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Clinical cancer research : an official journal of the American Association for Cancer Research

Radiation Oncology & Pathology, Stanford University, Stanford, CA, USA. qle [at] stanford.edu

Release reference

Clin Cancer Res. 2012 Mar;18(6):1798-807

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