Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer.

Abstract

ALDH1 was highly expressed in nonmetastatic CRC, but expression was lost with advancing stage. ALDH1 could be an effective therapeutic target in early CRC but not late-stage disease.

No correlation was found between ALDH1 and disease prognosis.

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Subjects

• Colorectal Neoplasms
• Humans
• Isoenzymes
• Neoplasm Staging
• Neoplastic Stem Cells
• Retinal Dehydrogenase

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Authors

• Crystal J Hessman
• Emily J Bubbers
• Kevin G Billingsley
• Daniel O Herzig
• Melissa H Wong

Publication date

2012-04-23

Journal

Journal topics

• General Surgery

Language

Eng.

Copyright

Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L223, Portland, OR 97239, USA. hessmanc [at] ohsu.edu

Release reference

Am J Surg. 2012 May;203(5):649-53

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