Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3.

Abstract

These findings support the enrichment of large, rare CNVs in ADHD and implicate duplications at 15q13.3 as a novel risk factor for ADHD. With a frequency of 0.6% in the populations investigated and a relatively large effect size (odds ratio=2.22, 95% confidence interval=1.5–3.6), this locus could be an important contributor to ADHD etiology.

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Subjects

• Adolescent
• Attention Deficit Disorder with Hyperactivity
• Canada
• Causality
• Child
• Child, Preschool
• Female
• Gene Dosage
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Great Britain
• Humans
• In Situ Hybridization, Fluorescence
• Inheritance Patterns
• Polymorphism, Single Nucleotide
• Receptors, Nicotinic
• Segmental Duplications, Genomic
• United States

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Authors

• Nigel M Williams
• Barbara Franke
• Eric Mick
• Richard J L Anney
• Christine M Freitag
• Michael Gill
• Anita Thapar
• Michael C O'Donovan
• Michael J Owen
• Peter Holmans
• Lindsey Kent
• Frank Middleton
• Yanli Zhang-James
• Lu Liu
• Jobst Meyer
• Thuy Trang Nguyen
• Jasmin Romanos
• M

Publication date

2012-03-14

Journal

Journal topics

• Psychiatry

Language

Eng.

Copyright

The American journal of psychiatry

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, and School of Medicine, Cardiff University, Cardiff, UK. williamsnm [at] cf.ac.uk

Release reference

Am J Psychiatry. 2012 Feb;169(2):195-204

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