Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.

Abstract

In addition to reducing LDL oxidation, the intake of polyphenol-rich olive oil reduces CD40L gene expression, its downstream products, and related genes involved in atherogenic and inflammatory processes in vivo in humans.

These findings provide evidence that polyphenol-rich olive oil can act through molecular mechanisms to provide cardiovascular health benefits.

This trial was registered at www.controlled-trials.com as ISRCTN09220811.

Full Text

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Subjects

• Adult
• Antioxidants
• Atherosclerosis
• CD40 Ligand
• Cross-Over Studies
• Down-Regulation
• Humans
• Leukocytes, Mononuclear
• Lipoproteins, LDL
• Male
• Middle Aged
• Oxidation-Reduction
• Oxidative Stress
• Phenylethyl Alcohol
• Plant Oils
• Polyphenols
• Receptors, Adrenergic, beta-2
• Receptors, Interleukin-8
• Signal Transduction
• Young Adult

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Authors

• Olga Castañer
• María-Isabel Covas
• Olha Khymenets
• Kristiina Nyyssonen
• Valentini Konstantinidou
• Hans-Franz Zunft
• Rafael de la Torre
• Daniel Muñoz-Aguayo
• Joan Vila
• Montserrat Fitó

Publication date

2012-04-23

Journal

Journal topics

• Nutritional Physiological Phenomena

Language

Eng.

Copyright

Cardiovascular Risk and Nutrition, Research Groups of Institut Mar d'Investigacions Mèdiques-Research Institute Hospital del Mar, Barcelona, Spain.

Release reference

Am J Clin Nutr. 2012 May;95(5):1238-44

Related books

• Books of Antioxidants
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• Books of Cross-Over Studies
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• Books of Leukocytes, Mononuclear
• Books of Lipoproteins, LDL
• Books of Nutritional Physiological Phenomena
• Books of Oxidation-Reduction
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