Diagnosis of patients with immediate hypersensitivity to beta-lactams using retest.

Abstract

These results indicate that a diagnostic protocol based on the combination of skin testing and in vitro determination of specific IgE antibodies plus, if required, drug provocation testing is an appropriate procedure for evaluating immediate hypersensitivity reactions to beta-lactams. Because the sensitivity of skin testing and in vitro IgE assays is not optimal and a considerable proportion of patients are tolerant, drug provocation tests are necessary to achieve the diagnosis or confirm tolerance. A large percentage of patients (23%) were diagnosed using retest.

Full Text

• Esmon Publicidad - full-text pdf

Subjects

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents
• Child
• Drug Hypersensitivity
• Female
• Humans
• Hypersensitivity, Immediate
• Immunoglobulin E
• Male
• Middle Aged
• Skin Tests
• beta-Lactams

Similar articles

• Basophil activation and sulfidoleukotriene production in patients with immediate allergy to betalactam antibiotics and negative skin tests. (2005-03-01)
• Specific IgE determination in the diagnosis of beta-lactam allergy. (1997-01-21)
• Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction. (2004-06-15)
• Diagnosis of immediate-type beta-lactam allergy in vitro by flow-cytometric basophil activation test and sulfidoleukotriene production: a multicenter study. (2009-05-29)
• Assessment of a new brand of determinants for skin testing in a large group of patients with suspected beta-lactam allergy. (2007-08-14)
• In vitro diagnosis of immediate allergic reactions to drugs: an update. (2010-05-13)
• Diagnosis and management of drug hypersensitivity reactions. (2011-02-28)
• Glucocorticoid hypersensitivity as a rare but potentially fatal side effect of paediatric asthma treatment: a case report. (2008-06-30)
• Antigen specific quantification of sulfidoleukotrienes in patients allergic to Betalactam antibiotics. (2005-05-03)

Authors

• I García Núñez
• M J Barasona Villarejo
• M A Algaba Mármol
• C Moreno Aguilar
• F Guerra Pasadas

Publication date

2012-03-27

Journal

Journal topics

• Hypersensitivity
• Immunity

Language

Eng.

Copyright

Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologia

Servicio de Alergología, Hospital Universitario Reina Sofía, Córdoba, Spain. h62ganui [at] hotmail.com

Release reference

J Investig Allergol Clin Immunol. 2012 ;22(1):41-7

Related books

• Books of Anti-Bacterial Agents
• Books of Drug Hypersensitivity
• Books of Hypersensitivity
• Books of Hypersensitivity, Immediate
• Books of Immunity
• Books of Immunoglobulin E
• Books of Skin Tests
• Books of beta-Lactams