The cardiac mitochondrial proteome contains low amounts of proteases and is remarkably stable in isolation.
Oxidative damage lowers the proteolytic capacity of cardiac mitochondria and reduces substrate availability for mitochondrial proteases.
The 20S proteasome preferentially degrades specific substrates in the mitochondria and may contribute to cardiac mitochondrial proteostasis.
2012-04-27
Eng.
Circulation research
Department of Physiology, UCLA, Los Angeles, CA 90095, USA.
Circ Res. 2012 Apr;110(9):1174-8
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