Chromosome-selective sequencing of maternal plasma cell-free DNA for first-trimester detection of trisomy 21 and trisomy 18.

Abstract

In this study, chromosome-selective sequencing of cell-free DNA separated all cases of trisomy 21 and 98% of trisomy 18 from euploid pregnancies.

Full Text

• DOI - American journal of obstetrics and gynecology (DOI)
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Subjects

• Adult
• Case-Control Studies
• Chromosomes, Human, Pair 18
• DNA
• DNA Mutational Analysis
• Down Syndrome
• False Positive Reactions
• Female
• Humans
• Pregnancy
• Pregnancy Trimester, First
• Risk
• Sensitivity and Specificity
• Trisomy

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Authors

• Ghalia Ashoor
• Argyro Syngelaki
• Marion Wagner
• Cahit Birdir
• Kypros H Nicolaides

Publication date

2012-04-02

Journal

Journal topics

• Gynecology
• Obstetrics

Language

Eng.

Copyright

American journal of obstetrics and gynecology

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, King's College, University of London, London, England, UK.

Release reference

Am J Obstet Gynecol. 2012 Apr;206(4):322.e1-5

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