Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers.

Abstract

The regulatory effects of nicotine in the brain (ie, tobacco smoking-induced upregulation of β(2)*-nAChRs) seem to be distinctly different between men and women, and female sex steroid hormones likely have a role in this regulation.

These findings suggest an underlying neurochemical mechanism for the reported behavioral sex differences.

To treat female smokers more effectively, it is critical that nonnicotinic-mediated medications should be explored.

Full Text

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Subjects

• Adult
• Azetidines
• Behavior, Addictive
• Brain
• Depression
• Estradiol
• Female
• Functional Neuroimaging
• Humans
• Iodine Radioisotopes
• Male
• Nicotinic Antagonists
• Progesterone
• Pyridines
• Radioligand Assay
• Receptors, Nicotinic
• Sex Characteristics
• Smoking
• Substance Withdrawal Syndrome
• Tomography, Emission-Computed, Single-Photon

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Authors

• Kelly P Cosgrove
• Irina Esterlis
• Sherry A McKee
• Frederic Bois
• John P Seibyl
• Carolyn M Mazure
• Suchitra Krishnan-Sarin
• Julie K Staley
• Marina R Picciotto
• Stephanie S O'Malley

Publication date

2012-04-04

Journal

Journal topics

• Mental Disorders
• Psychiatry

Language

Eng.

Copyright

Archives of general psychiatry

Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA. kelly.cosgrove [at] yale.edu

Release reference

Arch Gen Psychiatry. 2012 Apr;69(4):418-27

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