Hepatic metabolism of heme in rats after exposure to benzene, gasoline and kerosene.

Abstract

delta-Aminolevulinic acid (ALA) synthetase, delta-ALA dehydratase and heme oxygenase activities were studied in the liver of albino rats, 3 and 20 h after i.p. administration of benzene, gasoline, and kerosene. delta-ALA synthetase activity was increased markedly after benzene administration, while gasoline and kerosene treated groups showed decreased enzyme activity.

Inhibition of delta-ALA dehydratase activity was observed in all three groups, but heme oxygenase activity was unchanged.

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Subjects

• 5-Aminolevulinate Synthetase
• Animals
• Benzene
• Female
• Gasoline
• Heme
• Heme Oxygenase (Decyclizing)
• Kerosene
• Liver
• Petroleum
• Porphobilinogen Synthase
• Rats

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Authors

• G S Rao
• K P Pandya

Publication date

1981-07-20

Journal

Journal topics

• Toxicology

Language

Eng.

Copyright

Archives of Toxicology

Release reference

Arch Toxicol. 1980 Dec;46(3-4):313-7

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