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Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease.| Authors: | X Roblin, J M Phelip, M Genevois, V Ducros, B Bonaz | | Language: | Eng. | | Date: | 21-03-2007 | | Journal: | Alimentary pharmacology
(0269-2813)
| | Release: | Aliment Pharmacol Ther. 2007 Apr;25(7):797-804 | |
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Abstract:
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BACKGROUND:
A high prevalence of osteoporosis is observed in Crohn's disease. Recent data have shown that homocysteinaemia is an important risk factor in low-bone mineralization and fracture.
AIM:
To look for an association between homocysteinaemia and low-bone mineralization in Crohn's disease patients.
PATIENTS AND
METHODS:
Ninety-two consecutive patients (sex ratio M/F 0.87; mean age: 36.6 +/- 13.2 years) were recruited between 2003 and 2005. Bone densitometry was performed on inclusion. The following parameters were analysed: age, sex, Crohn's Disease Activity Index, duration and extent of Crohn's disease, smoking status, corticosteroid treatment, immunosuppressive drugs, plasma homocysteine, folate and vitamin B12 concentration.
RESULTS:
The prevalence of a high homocysteine level (>15 micromol/L) was 60%. Osteoporosis and low-bone mineralization observed in 26 (28%), and 60 (65%) patients, respectively. On a multivariate analysis, associated factors for osteoporosis and low-bone mineralization were respectively: hyperhomocysteinaemia (OR: 61.4; CI: 95: 23-250; P < 0.001), and ileal Crohn's disease [OR: 13.8; CI: 95: 2.5-150; P = 0.036] for osteoporosis and hyperhomocysteinaemia [OR: 63.7; CI: 95: 8.5-250; P < 0.001] and disease duration of at least 5 years [OR: 11.4; CI: 95: 1.31-99; P = 0.039] for low-bone mineralization. Results were similar whichever site osteoporosis was detected.
CONCLUSION:
Hyperhomocysteinaemia was observed in 60% of our Crohn's disease patients and was strongly associated with low-bone mineralization and osteoporosis (OR: 61.4).
| | Copyright: | Alimentary pharmacology
Department of Gastroenterology and Liver Diseases, CHU de Grenoble, Grenoble, France. xroblin@chu-grenoble.fr | | Full text: |  EBSCO - HTML (needs subscription) | | Terms: | Absorptiometry, Photon, Adult, Bone Density, Crohn Disease, Female, Humans, Hyperhomocysteinemia, Male, Middle Aged, Osteoporosis, Risk Factors, Vitamin B Deficiency | | |
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