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Should we consider hypohidrotic ectodermal dysplasia as a possible risk factor for malignant melanoma?| Authors: | Stamatis Gregoriou, Dimitris Rigopoulos, Theognosia Vergou, Chrysovalantis Korfitis, George Menegakis, George Kontochristopoulos | | Language: | Eng. | | Date: | 18-10-2007 | | Journal: | Journal of cutaneous medicine and surgery
(1203-4754)
| | Release: | J Cutan Med Surg. ;11(5):188-90 | |
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Abstract:
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BACKGROUND:
Hypohidrotic ectodermal dysplasia (HED) is a rare multisystem disorder that typically affects hair, teeth, nails, and sweat glands in combination with abnormalities of ectodermal originated tissues.
OBJECTIVE:
To raise the issue of whether heightened awareness is required in the follow-up of pigmented lesions in patients with HED. METHODS/
RESULTS:
Two patients with HED are reported. The first had a history of two malignant melanomas, whereas the second presented with a novel malignant melanoma.
CONCLUSION:
Although a prospective epidemiologic study to determine the incidence of malignant melanoma in patients with HED is virtually impossible and the probable pathogenesis warrants further investigation, these two case reports, in conjunction with other recent reports associating other ectodermal dysplasias with malignant melanoma, suggest that heightened awareness might be prudent in the follow-up of pigmented lesions in patients with HED.
| | Copyright: | Journal of cutaneous medicine and surgery
Hyperhidrosis Clinic, Andreas Sygros Hospital, University of Athens, Athens, Greece. stamgreg@yahoo.gr | | Full text: |  EBSCO - HTML (needs subscription) | | Terms: | Ectodermal Dysplasia 1, Anhidrotic, Humans, Male, Melanoma, Middle Aged, Risk Factors, Skin Neoplasms | | |
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