Relationship between shift work and hypercholesterolemia in Japan.| Authors: | Mirei Dochi, Kouich Sakata, Mitsuhiro Oishi, Kumihiko Tanaka, Etsuko Kobayashi, Yasushi Suwazono | | Language: | Eng. | | Date: | 22-04-2008 | | Journal: | Scandinavian journal of work, environment
(0355-3140)
| | Release: | Scand J Work Environ Health. 2008 Feb;34(1):33-9 | |
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Abstract:
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OBJECTIVES:
The objective of this study was to clarify the influence of shift work on total cholesterol levels in serum in male Japanese workers.
METHODS:
Pooled logistic regression analyses were applied in this 14-year cohort study of 5510 male workers in a steel company. In examining how the adjustments influenced the results, the effect of shift work on the onset of hypercholesterolemia (>or=220 mg/dl, 5.7 mmol/l) was calculated by adjusting only for age (step 1), for age and lifestyle factors (drinking habit, smoking habit, habitual exercise) (step 2), for age, body mass index (BMI), and the laboratory data [creatinine, glycosylated hemoglobin A1c (HbA1c), aspartic aminotransferase, gamma-glutamyl transpeptidase (gamma-GTP), uric acid] (step 3), and for age, BMI, lifestyle factors, and the laboratory data (step 4).
RESULTS:
The odds ratio (OR) for shift work with respect to the onset of hypercholesterolemia was significant in step 4 [OR 1.10, 95% confidence interval (95% CI) 1.00-1.21, P-value 0.048], whereas the corresponding odds ratios in steps 1, 2, and 3 were not significant. In step 4, the other significant covariates were age (OR 1.01, 95% CI 1.00-1.02), BMI (OR 1.07, 95% CI 1.05-1.09), HbA1c (OR 1.07, 95% CI 1.02-1.11), gamma-GTP (OR 1.03, 95% CI 1.02-1.04) and alcohol consumption (OR 0.89, 95% CI 0.81-0.99).
CONCLUSIONS:
In the present study, shift work was shown to be a potential risk factor for hypercholesterolemia among male Japanese workers. However, no consistent association was found between shift work and hypercholesterolemia in the hierarchical evaluation of the statistical model. The present study could not provide well-established evidence for a relationship between shift work and hypercholesterolemia.
| | Copyright: | Scandinavian journal of work, environment
Department of Occupational and Environmental Medicine (A2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. muetani@faculty.chiba-u.jp | | Full text: | | | |
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