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Fine-tuned growth phase control of dps, encoding a DNA protection protein, by FIS and H-NS.| Authors: | Karin Schnetz | | Language: | Eng. | | Date: | 23-05-2008 | | Journal: | Molecular microbiology
(1365-2958)
| | Release: | Mol Microbiol. 2008 Jun;68(6):1345-7 | |
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Abstract:
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Dps, a ferritin-like DNA-binding protein, protects bacterial DNA against oxidative stress and hyper-compacts the nucleoid into a crystalline-like structure. In Escherichia coli, transcription of dps from a single promoter is directed by sigma S-RNA polymerase in stationary phase and by sigma 70-RNA polymerase in fast-dividing cells exposed to oxidative stress. In this issue of Molecular Microbiology, Grainger and co-workers demonstrate that the nucleoid-associated proteins, FIS and H-NS, control sigma factor selection at the dps promoter by a novel mechanism. The finding suggests a simple mechanism of growth phase control of Dps production and has implications for the response to oxidative stress by pathogenic enterobacteria.
| | Copyright: | Molecular microbiology
Institute for Genetics, University of Cologne, Cologne, Germany. schnetz@uni-koeln.de | | Full text: |  EBSCO - HTML (needs subscription) | | |
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