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Cytokine profile of Armenian patients with Familial Mediterranean fever.| Authors: | G P Manukyan, K A Ghazaryan, Zh A Ktsoyan, M V Tatyan, Z A Khachatryan, G S Hakobyan, V A Mkrtchyan, D Kelly, A Coutts, R I Aminov | | Language: | Eng. | | Date: | 16-06-2008 | | Journal: |
(1873-2933)
| | Release: | Clin Biochem. 2008 Jul;41(10-11):920-2 | |
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Abstract:
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OBJECTIVES:
Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. DESIGN AND
METHODS:
The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).
RESULTS:
In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.
CONCLUSIONS:
Inflammation in FMF involves Treg and Th17 lineages.
| | Copyright: |
Group of Molecular and Cellular Immunology and Laboratory of Molecular Genetics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia. | | Full text: |  EBSCO - HTML (needs subscription) | | |
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