Birth weight of infants after maternal exposure to typical and atypical antipsychotics: prospective comparison study.

Authors:	James J Newham, Simon H Thomas, Karine MacRitchie, Patricia R McElhatton, R Hamish McAllister-Williams
Language:	Eng.
Date:	02-05-2008
Journal:	The British journal of psychiatry : the journal of mental science (0007-1250)
Release:	Br J Psychiatry. 2008 May;192(5):333-7
Abstract:	BACKGROUND: The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown. AIMS: To determine whether atypical and typical antipsychotics differ in their effects on birth weight after maternal exposure during pregnancy. METHOD: Prospective data on gestational age and birth weight collected by the National Teratology Information Service for infants exposed to typical (n=45) and atypical (n=25) antipsychotics was compared with data for a reference group of infants (n=38). RESULTS: Infants exposed to atypical antipsychotics had a significantly higher incidence of large for gestational age (LGA) than both comparison groups and a mean birth weight significantly heavier than those exposed to typical antipsychotics. In contrast those exposed to typical antipsychotics had a significantly lower mean birth weight and a higher incidence of small for gestational age infants than the reference group. CONCLUSIONS: In utero exposure to atypical antipsychotic drugs may increase infant birth weight and risk of LGA.
Copyright:	The British journal of psychiatry : the journal of mental science University of Newcastle, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK. R.H.McAllister-Williams@ncl.ac.uk
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