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Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression.| Authors: | Zola N Mannie, Ray Norbury, Susannah E Murphy, Becky Inkster, Catherine J Harmer, Philip J Cowen | | Language: | Eng. | | Date: | 02-05-2008 | | Journal: | The British journal of psychiatry : the journal of mental science
(0007-1250)
| | Release: | Br J Psychiatry. 2008 May;192(5):356-61 | |
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Abstract:
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BACKGROUND:
We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation.
AIMS:
To test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region involved in the integration of emotional and cognitive information.
METHOD:
Eighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task.
RESULTS:
Controls showed significant activation in the pregenual anterior cingulate cortex to both positive and negative words during the emotional Stroop task. This activation was absent in FH+ participants.
CONCLUSIONS:
Our findings show that people at increased familial risk of depression demonstrate impaired modulation of the anterior cingulate cortex in response to emotionally valenced stimuli.
| | Copyright: | The British journal of psychiatry : the journal of mental science
University Department of Psychiatry, Warneford Hospital, Oxford, UK. | | Full text: | | | |
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