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A report of Epstein-Barr virus-positive primary cutaneous natural killer-/T-cell lymphoma.| Authors: | Sareeta R S Parker, Alvin R Solomon, Joshua E Lane | | Language: | Eng. | | Date: | 23-06-2008 | | Journal: | Journal of the American Academy of Dermatology
(1097-6787)
| | Release: | J Am Acad Dermatol. 2008 Jul;59(1):157-61 | |
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Abstract:
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We describe a patient who presented with Epstein-Barr virus-positive tumor-stage primary cutaneous lymphoma. Our patient had previously been treated with oral methotrexate for long-standing rheumatoid arthritis. Tissue analysis revealed large tumor cells that were surface CD2- and CD3-positive; T-cell-restricted intracellular antigen-positive; CD56-, CD20-, and CD30-negative; and stained positively for Epstein-Barr virus. Our case is noteworthy for several reasons. Although the presence of rheumatoid arthritis and therapy with methotrexate are putative risk factors for the development of immune suppression-related and Epstein-Barr virus-related lymphomas, the vast majority of lymphomas in this setting are of B-cell origin, and rarely are these primary cutaneous in nature. In addition, our patient's tumor displayed an unusual phenotype, with immunophenotypic features suggestive of an atypical natural killer-/T-cell lymphoma. Methotrexate was withdrawn, and our patient was successfully treated with local radiotherapy. She has remained in complete remission 28 months since diagnosis.
| | Copyright: | Journal of the American Academy of Dermatology
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. srsingh@emory.edu | | Full text: |  EBSCO - HTML (needs subscription) | | Terms: | Administration, Oral, Arthritis, Rheumatoid, Biopsy, Epstein-Barr Virus Infections, Female, Humans, Killer Cells, Natural, Lymphocyte Subsets, Lymphoma, T-Cell, Cutaneous, Methotrexate, Middle Aged, Skin | | |
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