Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.

Abstract

Mitochondrial oxidant generation initiates BAX- or BAK-dependent alveolar epithelial cell death, which contributes to hyperoxia-induced lung injury.

Full Text

• DOI - American journal of respiratory and critical care medicine (DOI)
• ProQuest Information and Learning - full-text online
• HighWire Press - full-text online

Temas

• Acute Lung Injury
• Animales
• Apoptosis
• Ciclofilinas
• Modelos Animales De Enfermedad
• Hiperoxia
• Varón
• Ratones
• Ratones Consanguineos C57bl
• Ratones Noqueados
• Mitocondria
• Estres Oxidativo
• Alveolos Pulmonares
• Ratas
• Ratas Sprague-dawley
• Especies De Oxigeno Reactivo
• Mucosa Respiratoria
• Superoxido Dismutasa
• bcl-2 Homologous Antagonist-Killer Protein
• bcl-2-Associated X Protein

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Autores

• G R Scott Budinger
• Gökhan M Mutlu
• Daniela Urich
• Saul Soberanes
• Leonard J Buccellato
• Keenan Hawkins
• Sergio E Chiarella
• Kathryn A Radigan
• James Eisenbart
• Hemant Agrawal
• Sara Berkelhamer
• Siegfried Hekimi
• Jianke Zhang
• Harris Perlman
• Paul T Schumacker
• Manu Jai

Fecha de publicación

2011-04-18

Revista

Temas de la revista

• Cuidados Criticos
• Enfermedades Respiratorias

Idioma

Eng.

Copyright

American journal of respiratory and critical care medicine

Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Street, Chicago, IL 60611, USA.

Referencia de entrega

Am J Respir Crit Care Med. 2011 Apr;183(8):1043-54

Libros relacionados

• Books of Acute Lung Injury
• Books of Alveolos Pulmonares
• Books of Animales
• Books of Apoptosis
• Books of Ciclofilinas
• Books of Cuidados Criticos
• Books of Enfermedades Respiratorias
• Books of Especies De Oxigeno Reactivo
• Books of Estres Oxidativo
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• Books of Mitocondria
• Books of Modelos Animales De Enfermedad
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• Books of Ratas Sprague-dawley
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• Books of Ratones Noqueados
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• Books of bcl-2 Homologous Antagonist-Killer Protein
• Books of bcl-2-Associated X Protein