Increased platelet activation in patients with stable and acute exacerbation of COPD.

Abstract

Patients with stable COPD have increased circulating platelet-monocyte aggregates compared with well-matched controls.

Platelet activation is further increased in patients with COPD during an acute exacerbation.

These findings identify a novel mechanism to explain the increased cardiovascular risk in COPD and suggest platelet inhibition as a plausible therapeutic target.

Full Text

• DOI - Thorax (DOI)
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online
• EBSCO - full-text online

Temas

• Plaquetas
• Progresion De Enfermedad
• Hembra
• Citometria De Flujo
• Volumen Expiratorio Forzado
• Humanos
• Varón
• Middle Aged
• Selectina P
• Activacion Plaquetaria
• Pronostico
• Enfermedad Pulmonar Obstructiva Crónica
• Recurrencia

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Autores

• John D Maclay
• David A McAllister
• Shonna Johnston
• Jennifer Raftis
• Catherine McGuinnes
• Andrew Deans
• David E Newby
• Nicholas L Mills
• William MacNee

Fecha de publicación

2011-08-18

Revista

Temas de la revista

• Torax

Idioma

Eng.

Copyright

Thorax

ELEGI/Colt Laboratories, Centre for Inflammation Research, Edinburgh University, Edinburgh, UK.

Referencia de entrega

Thorax. 2011 Sep;66(9):769-74

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